| 貨號 | 規(guī)格 | 價(jià)格 | 上海 | 北京 | 武漢 | 南京 | 購買數(shù)量 |
|---|---|---|---|---|---|---|---|
| S81311-5mg | ≥97% | ￥720.00 | 10 | - | - | - |
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| S81311-10mg | ≥97% | ￥1230.00 | 7 | - | - | - |
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| S81311-25mg | ≥97% | ￥2670.00 | 3 | - | - | - |
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| S81311-50mg | ≥97% | ￥4325.00 | 1 | - | - | - |
|
| S81311-100mg | ≥97% | ￥7200.00 | 1 | - | - | - |
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PLX7904, also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells.
| 產(chǎn)品描述： | PLX7904, also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells. | ||||||||||||||||||||
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| 靶點(diǎn)： | Raf | ||||||||||||||||||||
| 體內(nèi)研究： | PLX7904 inhibits the COLO205 xenograft growth in eight mice per group | ||||||||||||||||||||
| 細(xì)胞實(shí)驗(yàn)： | Cells are treated with PB04(PLX7904) at different concentrations (0, 0.05, 0.1, 1, 5 μM) for 24 h. Cells are lysed and analyzed by Western blotting with phospho-MEK1/2, total MEK1/2, phospho-ERK1/2 and total ERK1/2 antibodies. (Only for Reference) | ||||||||||||||||||||
| 參考文獻(xiàn)： | 1. Zhang C, et al. Nature. 2015, 526(7574):583-586. 2. Le K, et al. Pigment Cell Melanoma Res. 2013, 26(4):509-517. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存條件： | -20°C | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
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